The Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy

The Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy

Acceptance of the fetal semi-allograft by the mother's immune system has become the focus of intensive research. CD4+ T cells are important actors in the establishment of pregnancy. Th1/Th2 paradigm has been expanded to include CD4+ regulatory T (Treg) and T helper 17 (Th17) cells. Pregnancy hormones exert very significant modulatory properties on the maternal immune system. In this review, we ...

B and T Lymphocyte Attenuator is a Target of miR-155 during Naive CD4+ T Cell Activation

Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear. Objective: To examine whether the B and T lymphocyte attenuator (BTLA) is a target of miR-155 during naïve CD4+ T cell activation. Methods: Firefly luciferase reporter plasmids pEZX-MT01-wild-type-BTLA and pEZX-MT01-mutant-BTLA were ...

Comparison of CD4+ and CD8+ T- lymphocyte in Helicobacter pylori-negative functional dyspepsia

T Lymphocyte Characteristics and Immune Tolerance During Human Pregnancy

To ensure a fruitful and healthy pregnancy, every maternal organ system needs to adapt to the novel physiological needs raised by the developing fetus. The maternal immune system is no exception. Since the conceptus is half of foreign origins, presenting paternal antigens, it is considered a semi-allograft to maternal immunity. Therefore, an immune tolerance must develop to avoid immunological ...

b and t lymphocyte attenuator is a target of mir-155 during naive cd4+ t cell activation

background: microrna-155 (mir-155) is upregulated during t cell activation, but the exact mechanisms by which it influences cd4+ t cell activation remain unclear. objective: to examine whether the b and t lymphocyte attenuator (btla) is a target of mir-155 during naïve cd4+ t cell activation. methods: firefly luciferase reporter plasmids pezx-mt01-wild-type-btla and pezx-mt01-mutant-btla were c...